abstract：:Studies of the effects of hypoglycemia on the brain using neurocognitive testing have suggested that mainly complex functions subserved by secondary and tertiary cortex are affected by mild to moderate hypoglycemia and that intensively treated patients with Type I diabetes mellitus (T1DM) may have altered sensitivity ...

journal_title：Journal of neuroscience research

authors： Driesen NR,Goldberg PA,Anderson AW,Tang L,Flanagan DE,Sherwin RS,Gore JC

更新日期：2007-02-15 00:00:00

abstract：:Lithium, the most prevalent treatment for manic-depressive illness, might have a neuroprotective effect after brain injury. In culture, lithium can exert neurotoxic effects associated with reduction in polyamine synthesis but neuroprotective effects as cultured neurons mature. Cumulative evidence suggests that lithium...

journal_title：Journal of neuroscience research

authors： Gilad GM,Gilad VH

更新日期：2007-02-15 00:00:00

abstract：:Inhibitors of differentiation (Id) play an essential role in the neurogenesis of the central nervous system. However, the expression and function of Id in the development of cochlear sensory epithelial cells have yet to be elucidated. In this study, we demonstrate the Id1 gene was expressed in the rapidly growing otoc...

journal_title：Journal of neuroscience research

authors： Ozeki M,Hamajima Y,Feng L,Ondrey FG,Schlentz E,Lin J

更新日期：2007-02-15 00:00:00

abstract：:Recent evidence has demonstrated that neural stem cells (NSC) can be expanded from a variety of sources, including embryos, fetuses, and adult bone marrow and brain tissue. We have previously reported the generation of adult rat bone marrow-derived cellular spheres that are morphologically and phenotypically similar t...

journal_title：Journal of neuroscience research

authors： Zeng Z,Yuan X,Liu G,Zeng X,Zeng X,Ng H,Chen H,Jiang T,Akasaki Y,Kessey K,Black KL,Yu JS

更新日期：2007-02-01 00:00:00

abstract：:Although alterations in adenylate cyclase (AC) activity and somatostatin (SRIF) receptor density have been reported in Alzheimer's disease, the effects of amyloid beta-peptide (Abeta) on these parameters in the hippocampus are unknown. Our aim was to investigate whether the peptide fragment Abeta(25-35) can affect the...

journal_title：Journal of neuroscience research

authors： Burgos-Ramos E,Hervás-Aguilar A,Puebla-Jiménez L,Boyano-Adánez MC,Arilla-Ferreiro E

更新日期：2007-02-01 00:00:00

abstract：:The discharge behavior of neurons depends on a variable expression and sorting pattern of voltage-dependent potassium (Kv) channels that changes during development. The rodent retina represents a neuronal network whose main functions develop after birth. To obtain information about neuronal maturation we analyzed the ...

journal_title：Journal of neuroscience research

authors： Höltje M,Brunk I,Grosse J,Beyer E,Veh RW,Bergmann M,Grosse G,Ahnert-Hilger G

更新日期：2007-01-01 00:00:00

abstract：:Human fetal brain is a potential source of neural stem cells (NSCs) for cell replacement therapy in neurodegenerative diseases. We explored whether NSCs isolated from cortex and striatum of human fetuses, aged 6-9 weeks post-conception, maintain their regional identity and differentiate into specific neuron types in c...

journal_title：Journal of neuroscience research

authors： Kallur T,Darsalia V,Lindvall O,Kokaia Z

更新日期：2006-12-01 00:00:00

abstract：:Netrin-1 regulates axon extension during embryonic development and is expressed by neurons and myelinating oligodendrocytes in the adult CNS. To investigate the potential role of netrin-1 after spinal cord injury, we examined the expression of netrin-1 and netrin receptors after sagittal myelotomy in adult rats. This ...

journal_title：Journal of neuroscience research

authors： Manitt C,Wang D,Kennedy TE,Howland DR

更新日期：2006-12-01 00:00:00

abstract：:Ionotropic glutamate receptors, N-methyl-d-aspartate receptors (NMDARs) and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs), are densely distributed in the mammalian brain and actively regulate a variety of cellular activities. Expression and function of these receptors are also under a tig...

journal_title：Journal of neuroscience research

authors： Wang JQ,Liu X,Zhang G,Parelkar NK,Arora A,Haines M,Fibuch EE,Mao L

更新日期：2006-12-01 00:00:00

abstract：:Neural stem cells reside in defined areas of the adult mammalian brain, including the dentate gyrus of the hippocampus. Rat neural stem/progenitor cells (NSPCs) isolated from this region retain their multipotency in vitro and in vivo after grafting into the adult brain. Recent studies have shown that endogenous or gra...

journal_title：Journal of neuroscience research

authors： Faijerson J,Tinsley RB,Apricó K,Thorsell A,Nodin C,Nilsson M,Blomstrand F,Eriksson PS

更新日期：2006-11-15 00:00:00

abstract：:Gangliosides, sialic acid-containing glycosphingolipids, are ubiquitously expressed in all eukaryotic cells and are localized primarily in the plasma membrane. For a rat pheochromocytoma cell line, PC12, which has been used frequently as a model for investigating events leading to neuronal differentiation, it is gener...

journal_title：Journal of neuroscience research

authors： Yanagisawa M,Ariga T,Yu RK

更新日期：2006-11-01 00:00:00

abstract：:Functional MRI (fMRI) on spinal cord-injured rodents at 4 and 8 weeks post injury (PI) is described. The paradigm for fMRI, based on electrical stimulation of rat paws, was automated using an in-house designed microprocessor-based controller that was interfaced to a stimulator. The MR images were spatially normalized ...

journal_title：Journal of neuroscience research

authors： Ramu J,Bockhorst KH,Mogatadakala KV,Narayana PA

更新日期：2006-11-01 00:00:00

abstract：:Neuronal progenitors in the adult hippocampus continually proliferate and differentiate to the neuronal lineage, and ischemic insult promotes hippocampal neurogenesis. However, newborn neurons show a progressive reduction in numbers during the initial few weeks, therefore, enhanced survival of newborn neurons seems to...

journal_title：Journal of neuroscience research

authors： Sasaki T,Kitagawa K,Yagita Y,Sugiura S,Omura-Matsuoka E,Tanaka S,Matsushita K,Okano H,Tsujimoto Y,Hori M

更新日期：2006-11-01 00:00:00

abstract：:It has been postulated that the pathogenesis of Parkinson's disease (PD) is associated with mitochondrial dysfunction. Rotenone, an inhibitor of mitochondrial complex I, provides models of PD both in vivo and in vitro. We investigated the neuroprotective effect of D-beta-hydroxybutyrate (bHB), a ketone body, against r...

journal_title：Journal of neuroscience research

authors： Imamura K,Takeshima T,Kashiwaya Y,Nakaso K,Nakashima K

更新日期：2006-11-01 00:00:00

abstract：:Tauopathies, including Alzheimer's disease (AD), are a group of neurodegenerative disorders characterized by the presence of intraneuronal filamentous inclusions of abnormally phosphorylated tau protein. In AD brains, it has been shown that the level of abnormally phosphorylated tau is higher than in age-matched contr...

journal_title：Journal of neuroscience research

authors： Blard O,Frébourg T,Campion D,Lecourtois M

更新日期：2006-10-01 00:00:00

abstract：:The activation of cellular inflammatory response is tightly linked to induced production of reactive oxygen species (ROS) and nitric oxide (NO), which in turn have been identified as important regulators of cellular iron metabolism. In the present study, we have used the microglia cell line BV-2 and the neuroblastoma ...

journal_title：Journal of neuroscience research

authors： Reis K,Hälldin J,Fernaeus S,Pettersson C,Land T

更新日期：2006-10-01 00:00:00

abstract：:We have previously shown in rat primary cultured mesencephalic cells that cyanide induces a high level of oxidative stress and necrotic death. To evaluate the mechanism of the cytotoxicity, the effects of cyanide on intracellular glutathione (GSH) pools and inducible nitric oxide synthase (iNOS)-mediated reactive nitr...

journal_title：Journal of neuroscience research

authors： Prabhakaran K,Li L,Borowitz JL,Isom GE

更新日期：2006-10-01 00:00:00

abstract：:Calpains and cathepsins are two families of proteases that play an important role in ischemic cell death. In this study, we investigated the effect of E64d, a mu-calpain and cathepsin B inhibitor, in the prevention of neuronal and endothelial apoptotic cell death after focal cerebral ischemia in rats. Rats underwent 2...

journal_title：Journal of neuroscience research

authors： Tsubokawa T,Yamaguchi-Okada M,Calvert JW,Solaroglu I,Shimamura N,Yata K,Zhang JH

更新日期：2006-09-01 00:00:00

abstract：:Accumulation of beta-amyloid protein (Abeta) in the brain is a hallmark of Alzheimer's disease (AD), and Abeta-mediated pathogenesis could result from increased production of Abeta or insufficient Abeta clearance by microglia, astrocytes, or the vascular system. Cell-surface receptors, such as scavenger receptors, mig...

journal_title：Journal of neuroscience research

authors： Nakamura K,Ohya W,Funakoshi H,Sakaguchi G,Kato A,Takeda M,Kudo T,Nakamura T

更新日期：2006-09-01 00:00:00

abstract：:Soluble amyloid beta protein (Abeta) oligomers have been considered recently to be responsible for the cognitive dysfunction that sets in prior to senile plaque formation in the Alzheimer's disease (AD) brain. By using the newly prepared antibody against oligomer Abeta, rather than fibrillar or monomer Abeta, we obser...

journal_title：Journal of neuroscience research

authors： Ishibashi K,Tomiyama T,Nishitsuji K,Hara M,Mori H

更新日期：2006-08-15 00:00:00

abstract：:We investigated the ability of human bone marrow stromal cell (hBMSC) treatment to reduce axonal loss in experimental autoimmune encephalomyelitis (EAE) mice. EAE was induced in SJL/J mice by injection with proteolipid protein (PLP). Mice were injected intravenously with hBMSCs or PBS on the day of clinical onset, and...

journal_title：Journal of neuroscience research

authors： Zhang J,Li Y,Lu M,Cui Y,Chen J,Noffsinger L,Elias SB,Chopp M

更新日期：2006-08-15 00:00:00

abstract：:Changes in dopamine (DA) D(1), D(2), D(3), and D(4) receptors and serotonin 5-HT(1A) and 5-HT(2A) receptors in rat forebrain regions were autoradiographically quantified after continuous infusion of JL 13 [(5-(4-methylpiperazin-1-yl)-8-chloro-pyrido[2,3-b][1,5]benzoxazepine fumarate] for 28 days with osmotic minipumps...

journal_title：Journal of neuroscience research

authors： Moran-Gates T,Massari C,Graulich A,Liégeois JF,Tarazi FI

更新日期：2006-08-15 00:00:00

abstract：:Studies have shown that individuals with both a history of traumatic brain injury and inheritance of apolipoprotein E-4 (ApoE4) allele are associated with a poor neurologic outcome and an increased risk for Alzheimer's disease. We assessed the hypothesis that thrombin released during brain injury causes an increase in...

journal_title：Journal of neuroscience research

authors： Mhatre M,Hensley K,Nguyen A,Grammas P

更新日期：2006-08-01 00:00:00

abstract：:As a neurotransmitter and neuromodulator, serotonin (5-HT) influences neuronal outgrowth in the nervous systems of several species. In PC12 cells, 5-HT is known to have neuritogenic effects, although the signal transduction pathway responsible for these effects is not understood. In this study, we hypothesized that a ...

journal_title：Journal of neuroscience research

authors： Homma K,Kitamura Y,Ogawa H,Oka K

更新日期：2006-08-01 00:00:00

abstract：:Heterothermic mammals such as ground squirrels tolerate ischemia and N-methyl-D-aspartate (NMDA) better than homeothermic mammals such as rats both in vivo and in vitro, and this tolerance is enhanced in the hibernating state. However, the cellular mechanisms underlying this tolerance remain unclear. NMDA receptors (N...

journal_title：Journal of neuroscience research

authors： Zhao HW,Ross AP,Christian SL,Buchholz JN,Drew KL

更新日期：2006-08-01 00:00:00

abstract：:The expression of different muscarinic receptor subtypes was analyzed in immature Schwann cells obtained from sciatic nerve of 2-day neonatal rats. By using RT-PCR analysis, we demonstrated the presence of M1, M2, M3, and M4 receptor subtypes in cultured Schwann cells, with M2 displaying the highest expression levels....

journal_title：Journal of neuroscience research

authors： Loreti S,Vilaró MT,Visentin S,Rees H,Levey AI,Tata AM

更新日期：2006-07-01 00:00:00

abstract：:Treatment of chromaffin cells with nitric oxide (NO) donors (SNP and SNAP) and peroxynitrite produces a time- and dose-dependent necrotic and apoptotic cell death. Necrotic cell death was characterized by both an increase in lactate dehydrogenase and ATP release and changes in nuclei and cell morphology (as seen with ...

journal_title：Journal of neuroscience research

authors： Vicente S,Pérez-Rodríguez R,Oliván AM,Martínez Palacián A,González MP,Oset-Gasque MJ

更新日期：2006-07-01 00:00:00

abstract：:Neural stem cells can be propagated in culture as neurospheres, yielding neurons and glial cells upon differentiation. Although the neurosphere model is widely used, the functional properties of the neurosphere-derived neurons have been only partially characterized, and it is unclear whether repeated passaging alters ...

journal_title：Journal of neuroscience research

authors： Pagani F,Lauro C,Fucile S,Catalano M,Limatola C,Eusebi F,Grassi F

更新日期：2006-06-01 00:00:00

abstract：:Accumulating evidence indicates an immunosuppressive role for CD4(+)CD25(+) regulatory T cells (Tregs) in autoimmune diseases. Although an impaired Treg function in patients with relapsing-remitting multiple sclerosis (RR-MS) has been reported recently, no information is available so far about Treg function in the pro...

journal_title：Journal of neuroscience research

authors： Venken K,Hellings N,Hensen K,Rummens JL,Medaer R,D'hooghe MB,Dubois B,Raus J,Stinissen P

更新日期：2006-06-01 00:00:00

abstract：:Ca(2+) influx through L-type Ca(2+) channels regulates several different cellular processes in developing Purkinje neurons, including activation of transcription factors and expression of cellular proteins. In the current studies, we examined the age dependence of these actions of Ca(2+) during the early developmental...

journal_title：Journal of neuroscience research

authors： Gruol DL,Quina LA,Netzeband JG,Nguyen D,Gullette CE

更新日期：2006-06-01 00:00:00

abstract：:After left unilateral cochlear ablation (UCA) in young adult guinea pigs, the appearance of plasticities in auditory pathways suggested altered gene expression and modified phenotypic behaviors of auditory neurons. Because phosphorylated cyclic-AMP response element-binding protein (CREB-P) is a transcription factor th...

journal_title：Journal of neuroscience research

authors： Mo Z,Suneja SK,Potashner SJ

更新日期：2006-05-15 00:00:00

abstract：:The purpose of this study was to determine if calpain-induced proteolysis was associated with retinal degeneration or dysfunction in the rat acute ocular hypertensive model. Acute glaucoma was produced by elevation of IOP to 120 mm Hg for 1 hr. Retinal degeneration was evaluated by H&E staining and apoptosis was deter...

journal_title：Journal of neuroscience research

authors： Oka T,Tamada Y,Nakajima E,Shearer TR,Azuma M

更新日期：2006-05-15 00:00:00

abstract：:The Rho GTPases are important regulators of neurite outgrowth and pathfinding. We have recently reported that a Rho-family guanine nucleotide exchange factor, GEFT, modulates dendrite spine morphology and basal neurite outgrowth in primary hippocampal neurons and Neuro2A cells, respectively. Here we demonstrate that G...

journal_title：Journal of neuroscience research

authors： Bryan BA,Cai Y,Liu M

更新日期：2006-05-15 00:00:00

abstract：:The gene mutated in the mouse open brain (opb) phenotype antagonizes sonic hedgehog-mediated signaling and encodes a small GTPase of the Rab family, Rab23. To date, the brain expression profile and exact mechanism of function of the Rab23 protein has remained unknown. Specific antibodies generated against Rab23 showed...

journal_title：Journal of neuroscience research

authors： Guo A,Wang T,Ng EL,Aulia S,Chong KH,Teng FY,Wang Y,Tang BL

更新日期：2006-05-01 00:00:00

abstract：:Brain injury and neuroinflammation are pathophysiologic contributors to acute and chronic neurologic disorders, which are progressive diseases not fully understood. Mammalian metallothioneins I and II (MT-I&II) have significant neuroprotective functions, but the precise mechanisms underlying these effects are still un...

journal_title：Journal of neuroscience research

authors： Penkowa M,Tio L,Giralt M,Quintana A,Molinero A,Atrian S,Vasák M,Hidalgo J

更新日期：2006-05-01 00:00:00

abstract：:The inner ear of humans and experimental animals demonstrate an abundance of glucocorticoid receptors (GR). Glucocorticoids (GC) are widely used to treat different hearing disorders; yet the mechanisms of GC action on the inner ear are unknown. We demonstrate how GR can directly modulate hearing sensitivity in respons...

journal_title：Journal of neuroscience research

authors： Tahera Y,Meltser I,Johansson P,Bian Z,Stierna P,Hansson AC,Canlon B

更新日期：2006-05-01 00:00:00

abstract：:Cell transplantation offers a potential new treatment for stroke. Animal studies using models that produce ischemic damage in both the striatum and the frontal cortex have shown beneficial effects when hNT cells (postmitotic immature neurons) were transplanted into the ischemic striatum. In this study, we investigated...

journal_title：Journal of neuroscience research

authors： Bliss TM,Kelly S,Shah AK,Foo WC,Kohli P,Stokes C,Sun GH,Ma M,Masel J,Kleppner SR,Schallert T,Palmer T,Steinberg GK

更新日期：2006-05-01 00:00:00

abstract：:Apoptosis and neuronal atrophy are commonly seen in patients infected with the human immunodeficiency virus type 1 (HIV-1) in the late phase of infection. The HIV-1 envelope glycoprotein gp120 has been suggested to be a causal agent of neuronal loss. Therefore, blocking gp120 neurotoxicity may be an effective way to r...

journal_title：Journal of neuroscience research

authors： Bachis A,Mocchetti I

更新日期：2006-04-01 00:00:00

abstract：:The interleukin (IL)-15-dependent immune responses of murine microglia were strongly affected by low concentrations of the ganglioside GD3. The ganglioside binding to IL-15 inhibited the proinflammatory effects of the cytokine, reducing IL-15-dependent T-cell proliferation as well as mRNA expression for IL-15Ralpha, p...

journal_title：Journal of neuroscience research

authors： Gómez-Nicola D,Doncel-Pérez E,Nieto-Sampedro M

更新日期：2006-04-01 00:00:00

abstract：:The central nervous system (CNS) is considered a nonpermissive environment for axonal regeneration because of the presence of myelin and associated repulsive molecules. However, neural cells transplanted to the CNS preferably migrate and extend their fibers in white matter areas. We previously showed that white matter...

journal_title：Journal of neuroscience research

authors： Fang Z,Forslund N,Takenaga K,Lukanidin E,Kozlova EN

更新日期：2006-03-01 00:00:00